Gestational gigantomastia complicated by pseudo-angiomatous stromal hyperplasia - a multidisciplinary management approach.

SUMMARY: Gestational gigantomastia is a rare condition typified by disproportionate bilateral breast enlargement in pregnant women, resulting in skin thinning, ulceration, and bleeding. Less than sixty cases have been documented worldwide, and only one other in South Africa. Pseudo-angiomatous stromal hyperplasia (PASH) is a rare benign proliferation of stromal tissue in a tumorous or diffuse pattern. This, to the best of our knowledge, is the first published case, a 27-year-old human immunodeficiency virus (HIV) positive woman, to present with both conditions concurrently. Medical management with cabergoline was initiated and, seven months post-delivery, a novel Goldilocks mastectomy was performed with acceptable outcomes.

The Immunohistochemical Profile of Mammary Tissue in Women With Macromastia and Its Potential Clinical Implications.

Macromastia is an excessive, rapid, or slow growth of breast tissue in 1 or both breasts. While macromastia represents a benign lesion, it may cause breast, shoulder, back, and neck pain, poor posture, infections, and loss of nipple sensation. The pathogenesis of macromastia or hypertrophy of mammary tissue remains poorly understood. The purpose of this study is to investigate the immunohistochemical expression of several hormone receptors that may potentially influence the growth of breast tissue in women with macromastia. Immunohistochemical studies performed on representative sections of breast tissue from 63 patients diagnosed with macromastia included estrogen receptor, progesterone receptor, androgen receptor (AR), prolactin receptor, growth hormone receptor, and vascular endothelial growth factor. The expression of each stain was evaluated separately in the glandular epithelium and adipose tissue and calculated as an H-score. We observed that AR expression in breast glandular and adipose tissue in women with macromastia was significantly lower than benign, nonhypertrophic breast tissue of a control group. Although the analyses were controlled for the age, the fact the mean age and hormonal status differed between the patients and the controls could have affected the results. Additional large studies will be required to further verify this finding and increase the knowledge about the etiology of this condition and then guide pharmacological treatment of juvenile and/or idiopathic gigantomastia.

Mammoplasty Using Modified Superomedial Pedicle Technique in Severely Macromastia and Ptotic Breasts.

Mammoplasty is a surgery commonly used for macromastia. Many mammoplasty techniques are described, all with their specific pros and cons. However, the concern to avoid serious complications sometimes takes precedence, and the ideal result cannot be. For macromastia and severely ptotic breasts, usually the free nipple-areolar complex (NAC) mammoplasty technique is implemented. The results, however, may only be completely satisfactory regarding cosmetics. Loss of NAC, poor appearance, flabbiness, flattening, and ptosis are among the disadvantages of this technique. This study aimed to present the results of mammoplasty employing the superomedial pedicle technique without interrupting a macromastia central base with a pedicle length of 8 to 18 cm. According to the literature, many plastic surgeons recommend the free NAC rather than the pedicle technique because of the high complication rates in mammoplasties planned for highly ptotic breasts and macromastia. On the other hand, many free NAC techniques and their modifications with pedicle mammoplasty are described. The general conviction is that a standard method, protocol, or technique good for all patients does not exist. Our results are more acceptable both cosmetically and physiologically. Therefore, the superomedial pedicle technique can be modified to achieve ideal results where free NAC mammoplasty is considered for severe macromastia and ptotic patients. This combined method contributes to the viability of NAC by increasing blood supply to breast tissue and providing an ideal breast appearance.

Is free nipple grafting necessary in patients undergoing reduction mammoplasty for gigantomastia? A systematic review and meta-analysis.

BACKGROUND: Gigantomastia is a debilitating condition characterised by an excessive breast tissue growth impacting patients' quality of life. Surgically treatment options include the limited-length pedicle (LP) technique with free nipple grafting (FNG) and the elongated pedicle (EP) technique, which maintains continuity of the nipple-areola complex (NAC). Initially, despite the less satisfactory aesthetic outcome, FNG was preferred to treat hypertrophic breasts requiring resections over 1000 g of parenchymal and adipose tissue, due to concerns about NAC perfusion. Recently, many studies have questioned this indication. The aim of this study was therefore to evaluate the safety of the NAC-carrying EP technique in patients with gigantomastia eventually challenging the need for FNG. METHODS: A literature search using PubMed and Cochrane databases was performed, including studies describing the outcome of EP technique for resection exceeding 1000 g of breast tissue. Thereby, a meta-analysis was conducted to evaluate the rate of NAC necrosis, whereas a descriptive statistic was applied to assess all other surgery-associated complications. RESULTS: Twenty-five studies, encompassing 1355 patients (2656 breasts), were included. EP demonstrated an extremely low rate of NAC necrosis. Moreover, the analysis demonstrated a low rate of ischaemia-independent complications and a very high probability of maintaining NAC-sensation equal to the preoperative state. CONCLUSION: Current evidence indicates that the EP technique should be the preferred surgical method to treat gigantomastia with or without massive ptosis whenever indicated. It has proven to be safe. Furthermore, it yields superior aesthetic and functional outcomes, including breast feeding and preservation of NAC-sensation compared to the LP technique.

Absent meibomian glands and cone dystrophy in ADULT syndrome: identification by whole exome sequencing of pathogenic variants in two causal genes TP63 and CNGB3.

BACKGROUND: Ectrodactyly is a rare congenital limb malformation characterized by a deep median cleft of the hand and/or foot due to the absence of central rays. It could be isolated or depicts a part of diverse syndromic forms. Heterozygous pathogenic variants in the TP63 gene are responsible for at least four rare syndromic human disorders associated with ectrodactyly. Among them, ADULT (Acro-Dermato-Ungual-Lacrimal-Tooth) syndrome is characterized by ectodermal dysplasia, excessive freckling, nail dysplasia, and lacrimal duct obstruction, in addition to ectrodactyly and/or syndactyly. Ophthalmic findings are very common in TP63-related disorders, consisting mainly of lacrimal duct hypoplasia. Absent meibomian glands have also been well documented in EEC3 (Ectrodactyly Ectodermal dysplasia Cleft lip/palate) syndrome but not in ADULT syndrome. METHODS: We report a case of syndromic ectrodactyly consistent with ADULT syndrome, with an additional ophthalmic manifestation of agenesis of meibomian glands. The proband, as well as her elder sister, presented with congenital cone dystrophy.The molecular investigation was performed in the proband using Whole Exome Sequencing. Family segregation of the identified variants was confirmed by Sanger sequencing. RESULTS: Two clinically relevant variants were found in the proband: the novel de novo heterozygous missense c.931A > G (p.Ser311Gly) in the TP63 gene classified as pathogenic, and the homozygous nonsense pathogenic c.1810C > T (p.Arg604Ter) in the CNGB3 gene. The same homozygous CNGB3 variation was also found in the sister, explaining the cone dystrophy in both cases. CONCLUSIONS: Whole Exome Sequencing allowed dual molecular diagnoses: de novo TP63-related syndromic ectrodactyly and familial CNGB3-related congenital cone dystrophy.

Iatrogenic Cerebrospinal Fluid Breast Augmentation: Rare Complication of Ventriculoperitoneal Shunts and Management Strategies.

BACKGROUND: Ventriculoperitoneal shunt is one of the most common neurosurgical procedures in the treatment of hydrocephalus. There are reports of migration of the distal catheter to the breast pocket where cerebrospinal fluid then collects and can develop into a pseudocyst. There exist case reports in the literature of patients with prior breast augmentation who present with distal catheter migration from the peritoneal space into the breast tissue. We present a case series of 3 patients with preexisting breast augmentation who returned with unilateral breast enlargement after ventriculoperitoneal shunt. In all 3 patients, the distal catheter migrated out of the peritoneal space and was found to be coiled around the breast prosthesis. Additionally, we offer recommendations for managing these complications and a review of the literature. METHODS: We performed a systematic review without meta-analysis of studies involving management of shunt migration in the setting of preexisting breast implants. We present a case series of 3 patients whom we treated with breast cerebrospinal pseudocyst after migration of the distal catheter into the breast tissue. RESULTS: A total of 17 studies, dating from 2002 to 2022, met our inclusion and exclusion criteria and were selected for full review. Catheter migration occurred between 2 weeks and 9 months of initial shunt placement. All patients presented with unilateral breast enlargement and cerebrospinal fluid pseudocyst formation. All patients underwent revision shunt surgery. Surgical treatment strategies used included reimplantation of the distal catheter into the pleural space or ipsilateral or contralateral peritoneal space or complete removal of the entire shunt system. CONCLUSIONS: Breast-related ventriculoperitoneal shunt complication is a rare entity that is increasingly seen as more patients receive breast augmentation. Breast-related shunt complications most commonly present with cerebrospinal fluid pseudocyst formation in the breast. It is important for neurosurgeons to be aware of an underlying breast implant before placing a ventriculoperitoneal shunt. For patients who have migration of the distal catheter into the breast, a protocol for managing these situations should be followed to ensure no shunt infection and avoidance of future catheter migration complications with subsequent shunt revisions.

Mamas tuberosas: reconstrucción mediante tejido autólogo, sin prótesis / Tuberous breast: autologous tissue reconstruction, without implants

Introducción y objetivo: La mama tuberosa es una entidad malformativa muy frecuente en mujeres jóvenes y un reto por su frecuencia y complejidad quirúrgica. Exponemos la transición que hemos llevado a cabo en el manejo de las mamas tuberosas en el servicio público de Cirugía Plástica del Hospital General Universitario Dr. Balmis de Alicante (España), sustituyendo la técnica con prótesis por técnica que emplea en exclusiva tejido autólogo. Material y método: Estudio descriptivo, retrospectivo, revisando los últimos 101 casos realizados en nuestro servicio entre noviembre de 2010 y junio 2022. Recogemos datos acerca de las técnicas quirúrgicas, número de intervenciones necesarias, así como la tasa de complicaciones a corto y largo plazo entre la técnica con material protésico que realizamos de forma habitual hasta 2013 y la técnica con tejido autólogo que utilizamos posteriormente. Describimos la técnica utilizada para corregir la alteración de la forma y la asimetría de volumen de las mamas tuberosas mediante el uso de colgajos glandulares, lipoinjertos y pexias mamarias. Resultados: En el periodo descrito empleamos tejido autólogo de forma exclusiva en el 87% de los casos, el 81% correspondientes a grados II y III de Grolleau, con una media de 2.1 tiempos quirúrgicos. La técnica más utilizada fue la remodelación glandular asociada a lipoinjerto. El índice de complicaciones a medio y largo plazo fue menor en comparación con la reconstrucción habitual con prótesis. Conclusiones: Según nuestra experiencia, la cirugía de la mama tuberosa mediante el uso exclusivo de tejido autólogo en pacientes seleccionadas, permite corregir esta malformación sin recurrir al uso de material protésico, con resultados reproducibles y con menos complicaciones a medio y largo plazo en comparación con la reconstrucción habitual con prótesis.(AU)

Background and objective: Tuberous breast is a very common malformative entity in young women and a challenge due to its frequency and surgical complexity. We present our transition in the management of tuberous breasts of our public Plastic Surgery Service at the Dr. Balmis General University Hospital in Alicante (Spain), replacing technique with prosthetic material for exclusive technique with autologous tissue. Methods: Descriptive, retrospective study, reviewing the last 101 cases performed in our service between November 2010 and June 2022. Data have been collected about the surgical techniques, number of necessary interventions, as well as the rate of shortand long-term complications between the technique with prosthetic material that we routinely performed until 2013 and the technique with autologous tissue that we used subsequently. The technique used to correct the alteration in shape and volume asymmetry of the tuberous breast is described, through using glandular flaps, lipografts and mastopexy techniques. Results: In the period described, the use of autologous tissue exclusively has been carried out in 87% of the cases, 81% corresponding to Grolleau grades II and III, with an average of 2.1 surgical times. The most used technique was glandular remodeling associated with lipograft. The rate of complications in the medium and long term is lower compared to the usual technique with prostheses that we previously performed. Conclusions: According to our experience, treatment of the tuberous breast through the exclusive use of autologous tissue in selected patients, allows this malforation to be fixed without using prosthetic material, with a lower number of complications compared to reconstruction with prosthetic material.(AU)

Utilidad de la fotografía térmica como herramienta predictora de compromiso vascular del complejo areola-pezón / Utility of thermal photography as a predicting tool of vascular involvement of nippel-areolar complex

Introducción y objetivo: La viabilidad del complejo areola pezón (CAP) es un aspecto de vital importancia en cirugía mamaria. En estudios previos presentamos, con el uso de la mamografía 3D, que la revascularización de los CAP tras mastopexia no es ad-integrum y que existen patrones vasculares distintos en algunas pacientes después de ser sometidas a cirugía mamaria. Hay métodos para evaluar la circulación de los tejidos, no solo antes de la cirugía, sino durante el intraoperatorio, como son: la colorimetría, la indocianina verde y la termografía. Nuestro objetivo es presentar el uso de la termografía como predictor del compromiso vascular de los CAP durante la mastopexia. Material y método: Estudio prospectivo observacional en 37 pacientes (74 mamas) sometidas a mastopexia en las que realizamos mediciones de temperatura con cámara térmica portátil (Flirone pro®, modelo 435-0004-03) para teléfono inteligente (Apple, I-phone® 12, versión 16.1.1). Evaluamos resultados en cuanto a diferenciales de temperatura en 3 etapas de cirugía mamaria: inicial, intermedia y final. Resultados: El promedio de temperatura entre inicial y final de las pacientes con signos clínicos de compromiso vascular de los CAP fue superior a 4 grados de diferencial. En el resto de las pacientes, en las que los CAP no presentaron signos clínicos de cambios de flujo sanguíneo, el diferencial entre la temperatura inicial y la final fue menor de 3.1 grados. Conclusiones: Mantenerse a la vanguardia en la seguridad de la especialidad nos compromete a disponer de procedimientos seguros para nuestros pacientes. En nuestra experiencia, la termografía puede servir como herramienta predictora del compromiso vascular del C.A.P durante la cirugía mamaria.(AU)

Background and objective: The viability of the nipple areola complex is a vitally important aspect in breast surgery. In previous studies, with the use of 3D mammography, we presented that the revascularization of the NIC after mastopexy is not ad-integrum and that there are different vascular patterns in some patients after undergoing breast surgery. There are methods to evaluate tissue circulation, not only before surgery, but also during the intraoperative period, such as: colorimetry, indocyanine green, and thermography. Our objective is to present the use of thermography as a predictor of vascular compromise of the nipple-areola complexNIC during mastopexy. Methods: A prospective and observational study was carried out in 37 patients (74 breasts) who underwent mastopexies. Temperature was obtained using the Flir one pro® model 435-0004-03 portable thermal camera for smartphones (Apple® smartphone,I-phone12 version 16.1.1, evaluating temperature differentials in 3 stages of breast surgery: initial, intermediate and final. Results: The average temperature between initial and final in patients with clinical signs of vascular compromise of the nipple-areola complex was greater than 4 degrees. Rest of patients, with nipple-areola complex without clinical signs of blood flow changes, a differential between the initial and final temperature of <3.1 degrees was found. Conclusions: In our experience, thermography can serve as a predictive tool of vascular compromise of the nipple-areola complex during breast surgery.(AU)

Giant tubular adenoma of the breast in a child female – Case report / Adenoma tubular gigante de mama en mujer adolescente – caso clínico

Tubular adenoma of the breast is one of the rarest benign tumors and little is known about this entity. Some cases of giant tubular adenoma of breast have been reported, but till the moment the largest lesion described in literature was a case of a 18 cm tubular adenoma in 31-year-old women. In this case report of a 12-year-old patient, we present the largest giant tubular adenoma of the breast ever described. It was an atypical presentation, not only due to the tumor size, but also due to the absence of a clear cleavage plan with the breast tissue in the physical exam and its rapid growth. (AU)

El adenoma tubular de mama es uno de los tumores benignos más raros y poco se conoce sobre esta entidad. Se han reportado algunos casos de adenoma tubular gigante de mama, pero hasta el momento la lesión más grande descrita en la literatura fue un caso de adenoma tubular de 18 cm en una mujer de 31 años. En este caso clínico de una paciente de 12 años, presentamos el adenoma tubular gigante de mama más grande jamás descrito. Fue una presentación atípica, no solo por el tamaño del tumor, sino también por la ausencia de un plan de clivaje claro con el tejido mamario en el examen físico y su rápido crecimiento. (AU)

The Surgical Treatment of Tuberous Breast Deformity: A Review Article.

ABSTRACT: Tuberous breast is a common congenital deformity that might present as unilateral or bilateral breast base constriction, asymmetry, areolar herniation, hypoplasia, ptosis, and skin deficiency. Patients might present with one or more of the mentioned features, rendering a consensus about the optimal surgical technique to correct this deformity nonexistent. In our review article, we present the most common classifications of a tuberous breast, in addition to several surgical approaches that attempt to treat this deformity.

A Systematic Review of Outcomes and Complications of Tuberous Breast Surgery.

BACKGROUND: Tuberous breast is a complex congenital breast anomaly that can be challenging to correct surgically. OBJECTIVES: The authors conducted a systematic review with pooled analysis of data, with the aim of determining the effectiveness and complications related to operative management of the deformity. METHODS: Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were adopted in performing this systematic review. A simplified classification system for tuberous breast deformity was developed to accurately compare data and guide analysis. RESULTS: The review identified 38 studies, reporting a total of 897 patients undergoing tuberous breast surgery. The mean age of patients was 24 years (range 13-53 years). Mean follow-up was 39 months. A combination of tissue rearrangement and implant augmentation was the most common technique (73% of patients) followed by fat transfer alone (9%). Breast implants were employed in 83% of patients. The mean implanted volume per breast was 263 cc. Fat grafting was performed in 13% of patients and mean volume of fat grafted per breast was 185 cc. An overall complication rate of 20% was reported. Subjective assessment of patient satisfaction was 99%, and the mean score on BREAST-Q for satisfaction with clinical outcome was 86.7. Future studies should focus on robust study designs including randomized and cohort studies, use of patient-reported outcome measures, and long-term follow-up. CONCLUSIONS: The surgical techniques to correct tuberous breast deformity are safe, effective, and have a high satisfaction rate. Fat transfer has the capacity to provide promising results in treating tuberous breast deformity.

Mamoplastia de reducción y medialización del complejo areola-pezón en paciente acondroplásica con gigantomastia. Caso clínico / Reduction mammoplasty and nipple medialization in achondroplasic patient with gigantomastia. Case report

La acondroplasia es una enfermedad genética rara que representa la forma más común de enanismo de extremidades cortas. Existen pocos casos reportados de gigantomastia y subsecuente cirugía mamaria en esta población. Presentamos el caso de una paciente con acondroplasia, gigantomastia y medialización de pezón que requirió mamoplastia reductora y reposición de complejo areola pezón (CAP). Se utilizó la técnica de T invertida con pedículo inferior. La planeación quirúrgica y el correcto marcaje en pacientes acondroplásicos son pasos importantes para una cirugía exitosa teniendo en cuenta que las referencias anatómicas habituales no son guías confiables para un posicionamiento ideal de la mama en el tórax o del CAP en la mama. (AU)

Achondroplasia is a rare genetic disease representing the most common form of short-limb dwarfism, and there are a few case reports of gigantomastia and subsequent breast surgery in this patient population. We present the case of a patient with achondroplasia, gigantomastia and nipple medialization who required a reduction mammaplasty and reposition of the nipple areola complex (NAC). An inverted T technique with an inferior pedicle was used. Surgical planning and correct marking in achondroplasic patients are important steps for a successful surgery considering that common anatomical landmarks are not a reliable guide for ideally positioning the breast on the thoracic wall or the NAC on the breast. (AU)

Definitions of Abnormal Breast Size and Asymmetry: A Cohort Study of 400 Women.

BACKGROUND: Macromastia, micromastia and breast asymmetry have an impact on health and quality of life. However, there is scarce information addressing breast size and asymmetry frequency distribution in reference populations. OBJECTIVE: The current study aims to identify factors that influence breast size and symmetry and classifies abnormal breast sizes and breast asymmetries in an adult German population. METHODS: Breast base dimensions, breast volume, symmetry, and other breast anthropometric parameters of 400 German female patients were determined in a retrospective review of the MRI archives at our institution. Professional medical MRI-segmentation software was used for volume measurement. RESULTS: A total of 400 Patients were retrospectively enrolled. The patients had a mean age of 50 ± 12 years (min: 24; max: 82), mean BMI of 25.0 ± 5.0 (min: 14.7, max: 45.6), and a mean total breast volume of 976 ml (right: 973 ml, min: 64, max: 4777; left: 979 ml, min: 55, max: 4670). The strongest correlation of breast volume was observed with BMI (r = 0.834, p < 0.001), followed by breast base width (r = 0.799, p < 0.001). Smaller breasts have higher breast volume asymmetry ratios (r = - 0.124, p < 0.014). For a BMI between 18.5 and 24.9 kg/m2, micromastia is defined by breast volumes below 250 ml (5th percentile) and macromastia by volumes above 1250 ml (95th percentile). Abnormal breast volume asymmetry (< 5th and > 95th percentile) is equivalent to an absolute difference of approximately 25% relative to the smallest side (bidirectional asymmetry ratio 5th percentile - 19%; 95th percentile 26%). CONCLUSION: This study provides normative data of German women, as well as selected size-for-BMI percentiles and asymmetry ratio percentiles. The normative data may help to establish transparent and objective coverage criteria for health insurances. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Tratamiento de la macromastia sintomática en una unidad de mama. Resultados de la reducción mamaria evaluados mediante el cuestionario BREAST-Q / Treatment of symptomatic macromastia in a breast unit. Outcomes analysis of breast reduction using BREAST-Q

Introducción: El BREAST-Q (módulo reducción mamaria) es un cuestionario específico y validado para evaluar la reducción mamaria en el tratamiento de la macromastia sintomática, ofreciendo información sobre la calidad de vida y grado de satisfacción de las pacientes. Métodos: Estudio prospectivo de una cohorte de 34 pacientes tratadas mediante reducción mamaria bilateral, en una unidad de mama en 2017-2020, que fueron encuestadas con la versión adaptada al castellano del BREAST-Q. Las pacientes cumplimentaron el cuestionario en el mes previo a la cirugía y después de esta. Los cambios de las puntuaciones pre- y postoperatorias en los diferentes dominios se analizaron mediante la prueba de rangos con signo de Wilcoxon. La significación estadística fue determinada con valores de p<0,05. Resultados: El tiempo medio desde la cirugía a la encuesta postoperatoria fue 16 (DE 9) meses. Complicaciones o secuelas posquirúrgicas sucedieron en 14 (42%) pacientes con 23 eventos. Las puntuaciones preoperatorias, medianas y rango intercuartílico, en la satisfacción con las mamas (28, 26), bienestar psicológico (33, 14), físico (42, 19) y sexual (34, 14) mejoraron en la encuesta postoperatoria a (82, 15), (81,29), (82, 30) y (90, 38), respectivamente, con significación estadística, p<0,001. Conclusiones: La primera aplicación del BREAST-Q versión en castellano para españolas a pacientes con macromastia tratadas quirúrgicamente en una unidad de mama demuestra que la reducción mamaria mejora la calidad de vida de las pacientes y, que estas están muy satisfechas con el resultado de la cirugía y su cirujano, aunque la información recibida es mejorable. (AU)

Introduction: The BREAST-Q (breast reduction module) is a specific and validated questionnaire to evaluate breast reduction in the treatment of symptomatic macromastia, offering information on their quality of life and degree of satisfaction. Methods: Prospective study of a cohort of 34 patients treated by bilateral breast reduction in a breast unit in 2017–2020 surveyed with the Spanish version of BREAST-Q version 2. The statistical study to assess the effect of reduction, changes from the pre to postoperative scores of the domains were performed using the Wilcoxon signed rank test. Statistical significance was determined with P values <.05. Results: The mean time elapsed from surgery to the postoperative survey was 16 (SD 9) months. Post-surgical complications or sequelae occurred in 14 (42%) patients with 23 events. The preoperative scores, median and interquartile range, in satisfaction with the breasts (28, 26), psychological (33, 14), physical (42, 19) and sexual (34, 14) well-being improved in the postoperative survey to (82, 15), (81, 29), (82, 30) and (90, 38), respectively. These changes were statistically significant, P<.001. Conclusions: The first application of the BREAST-Q in its version in Spanish for Spanish women in patients with symptomatic macromastia treated surgically in a breast unit shows that breast reduction improves the quality of life of patients and that they are very satisfied with the outcome of the surgery and its surgeon, although the information received should clearly be improved. (AU)

Large-Volume Fat Grafting to the Breast With External Expansion Assist.

BACKGROUND: Large-volume autologous fat transfer (AFT) to the breast with external expansion has emerged as an alternative to alloplastic augmentation or reconstruction in appropriate patients. OBJECTIVES: Report the authors' technique for this procedure and experience with 49 consecutive patients of a single surgeon's practice from 2013 to 2021. METHODS: The authors performed a retrospective analysis of consecutive patients undergoing fat grafting to the breast with preexpansion. Patients were included if they had a clinical problem amenable to correction with large-volume fat injection and adequate donor sites, and were willing to undergo preexpansion. Data was collected through chart review and deidentified. Demographics, diagnosis, radiation status, volume grafted, complications, and adjunct procedures were recorded. RESULTS: Forty-nine patients underwent external expansion with AFT by a single surgeon. Twenty-three patients (47%) had hypoplastic indications, including tuberous breast deformity (n = 9) and Poland syndrome (n = 1). Seventeen patients (35%) had indications for secondary breast revision of previously placed implants. Nine patients (18%) utilized the procedure for primary oncologic breast reconstruction. A total of 71 procedures were performed, with an average of 1.45 procedures per patient. The average volume of fat grafted per breast was 372 mL for hypoplasia, 240 mL for secondary breast revision, and 429 mL for oncologic reconstruction. Concurrent procedures included implant exchange, implant removal, mastopexy, and breast reduction. Follow-up ranged from 1 to 84 (average = 20) months. CONCLUSIONS: The authors' experience shows promising results with external expansion and large-volume fat grafting to the breast.

Fibroadenoma gigante juvenil y cirugía de reconstrucción: reporte de un caso y revisión de la bibliografía / Giant juvenile fibroadenoma and reconstruction surgery: A case report and literature review

El fibroadenoma es la lesión mamaria benigna más frecuente en la mujer joven, siendo el fibroadenoma gigante juvenil una entidad que aparece principalmente en menores de 25 años. Con una etiología actualmente no bien establecida, se caracteriza por ser una lesión tipo masa mayor de 5cm que puede ocupar más del 80% de la mama y que presenta un importante crecimiento con las consecuencias físicas y psicológicas que ello conlleva. A pesar de ser una lesión benigna, su evolución progresiva con un rápido crecimiento obliga a descartar malignidad, lo cual ocurre en menos del 0,2% de los casos. El diagnóstico se basa en una correcta anamnesis, exploración física y pruebas complementarias, siendo preferible la ecografía. El estudio anatomopatológico mediante biopsia permite confirmar el diagnóstico clínico de benignidad o descartar malignidad ante una evolución sospechosa. El tratamiento es quirúrgico y consiste en la escisión completa de la lesión variando la técnica quirúrgica realizada (desde cirugía conservadora hasta mastectomía con reconstrucción) según el tamaño de la lesión, las características de la mama y la edad de la paciente. (AU)

Fibroadenoma is the most common benign breast lesion in young women, being the giant juvenile fibroadenoma an entity that appears mainly in those under 25 years. With an etiology currently not well established, it is described as a mass type lesion greater than 5cm or that occupies more than 80% of the breast and presents significant growth, with the physical and psychological consequences that this entails. Despite being a benign lesion, its fast evolution and growth makes it necessary to rule out malignancy, which occurs in less than 0.2% of the cases. The diagnosis is based on a correct anamnesis, physical examination and complementary tests, preferable with ultrasound. The anatomopathological study by biopsy allows to confirm the clinical diagnosis of benignity or to rule out malignancy in the event of a suspicious evolution. Its management is surgical and consists of complete excision of the lesion, varying the surgical technique performed (from conservative surgery to mastectomy with reconstruction) according to the size of the lesion, the characteristics of the breast, and the age of the patient. (AU)

Cerebral hemorrhage caused by shaking adult syndrome? Evidence from biomechanical analysis using 3D motion capture and finite element models.

The present study combined three-dimensional (3D) motion capture with finite element simulation to reconstruct a real shaking adult syndrome (SAS) case and further explore the injury biomechanics of SAS. The frequency at which an adult male can shake the head of another person, head-shaking amplitude, and displacement curves was captured by the VICON 3D motion capture system. The captured shaking frequency and shaking curve were loaded on the total human model for safety (THUMS) head to simulate the biomechanical response of brain injury when a head was shaken in anterior-posterior, left-right, and left anterior-right posterior directions at frequencies of 4 Hz (Hz), 5 Hz, 6 Hz, and 7 Hz. The biomechanical response of the head on impact in the anterior, posterior, left, left anterior, and right posterior directions at the equivalent velocity of 6 Hz shaking was simulated. The violent shaking frequency of the adult male was 3.2-6.8 Hz; head shaking at these frequencies could result in serious cerebral injuries. SAS-related injuries have obvious directionality, and sagittal shaking can easily cause brain injuries. There was no significant difference between the brain injuries caused by shaking in the simulated frequency range (4-7 Hz). Impact and shaking at an equivalent velocity could cause brain injuries, though SAS more commonly occurred due to the cumulative deformation of brain tissue. Biomechanical studies of SAS should play a positive role in improving the accuracy of forensic identification and reducing this form of abuse and torture in detention or places of imprisonment.